To study gene expression for vitamin d receptor (VDR) and calcium sensing receptor (CaSR) in patients with primary hyperparathyroidism (PHPT) and its correlation with clinical outcome
Implementing Organization
Postgraduate Institute of Medical Education and Research (PGIMER),Chandigarh
Principal Investigator
Dr. Sanjay Kumar Bhadada
Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012
CO-Principal Investigator
Dr. Madhu Khullar
Professor, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, Dr. Uma Nahar Saikia, Additional Professor, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, Dr. Naresh Sachdeva , Assistant Professor, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012
Project Overview
The present findings showed significant reductions in VDR mRNA expressions in adenomatous compared to normal parathyroid tissue. Consistent with these, immunohistochemistry also revealed reduction at both nuclear as well as cytoplasmic expression in adenoma cells.