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8849 result(s) found
Stem cell derived exosome therapy for clinical management of lung damage in critically-ill corona viral pneumonia patients

This study hypothesized that the immuno-modulatory and the reparative properties of MSC-derived exosomal fractions will aid in controlling the cytokine storm and the lung tissue regeneration in the critically ill COVID-19 patients.

Section: Medical Sciences (Research Project)
Related: Stem Cell Stem Cell derived exosome therapy for clinical management of lung damage in critically-III Corona viral Pneumonia patients Research Project › Medical Sciences Development of Development of state-of-the-art in-silico model to achieve targeted drug delivery against viral respiratory disorders Research Project › Engineering Sciences
Structural and mechanistic studies to understand SARS-CoV-2 ingress into human cells and its therapeutic intervention

The project aims structural and mechanistic studies on full-length and truncated spike-protein of SARS-CoV-2 with ACE2 receptor to provide a previously unattainable view of the interaction of viral protein with ACE2 receptor.

Section: Medical Sciences (Research Project)
Related: Structural & Structural & mechanistic studies to understand Sars-Cov-2 ingress into human cells & its therapeutic intervention Research Project › Medical Sciences Structural elucidation Structural elucidation of α-Synuclein-viral RNA G-quadruplex-DDX39A interaction triad Research Project › Life Sciences & Biotechnology Understanding the Understanding the regulation of gap junction protein Connexin 43 in Murine-β-Coronavirus, MHV induced acute and chronic phase inflammation by combining TNF-α, IL-10 and TGF- β signalling triad. Research Project › Life Sciences & Biotechnology Comparative Study Comparative Study of Topological Descriptors Among Some Well-known Antiviral Drugs Used for the Treatment of Covid-19 Patients Research Project › Pharmaceutical Sciences Unraveling the Unraveling the Influence of Ribosomal Frameshifting Elements Conformational Ensembles on Japanese Encephalitis Virus Pathogenesis Research Project › Life Sciences & Biotechnology
Structural, biochemical and computational investigation on the therapeutic targets of SARS-CoV-2 and structure-based drug discovery from Indian herbs

This project aims to determine the three-dimensional structure of Nsp1 and ORF6 proteins of SARS-CoV-2, which has different functions, yet is commonly responsible for the suppressed levels of host mRNA translation.

Section: Pharmaceutical Sciences (Research Project)
Related: Structural, biochemical Structural, biochemical & computational investigation on the therapeutic targets of Sars-Cov-2 & structure - based drug discovery from Indian herbs Research Project › Medical Sciences Design, Synthesis Design, Synthesis and Anti-Mycobacterial evaluation of Diversity Oriented Novel Pyrido-Pyrazine Scaffolds. Research Project › Chemical Sciences
Synthetic reconstruction of an attenuated SARS-CoV-2 virus for vaccine development and a high-content inhibitor screen

The project aims to create synthetic SARS- CoV-2 viral genome using chemically synthesised DNA and oligonucleotides.

Section: Life Sciences & Biotechnology (Research Project)
Related: Synthetic reconstruction Synthetic reconstruction of an attenuated Sars-Cov-2 virus for vaccine development & a high-content inhibitor screen Research Project › Medical Sciences
Targeting the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 for the development of inhibitors

The goal of this proposal is to devise potent small molecule inhibitors against SARS-CoV-2 RNA-dependant RNA polymerase (RdRp) based on the quinoline scaffold for COVID-19 treatment.

Section: Pharmaceutical Sciences (Research Project)
Related: Targeting the Targeting the RNA-depndent RNA polymerase (Rdrp) of Sars-Cov-2 for the development of inhibitors Research Project › Medical Sciences Identifying potential Identifying potential anti-COVID-19 compounds targeting the RNA dependent RNA polymerases (RdRp) of SARS-CoV-2 Research Project › Pharmaceutical Sciences Repurposing of Repurposing of drugs and validation of lead compounds against main protease and RNA dependent RNA polymerase of SARS-CoV-2 Research Project › Pharmaceutical Sciences Towards development Towards development of a potent antiviral against the Sars-Cov-2 by targeting the interaction between nucleocapsid protein & viral RNA Research Project › Medical Sciences Towards development Towards development of a potent antiviral against SARS–CoV-2 by targeting the interaction between nucleocapsid protein and viral RNA Research Project › Other
Understanding the role of SARS-CoV-2 virulence factor-Orf3a in modulating host cell responses: A way to identify host-directed therapy

The aim of this grant application is to understand the role of SARS-CoV-2 Orf3a in modulating host cell responses. To achieve this, the following objectives will be pursued: (i) determine Orf3a localisation in host cells and delineate sorting motifs

Section: Life Sciences & Biotechnology (Research Project)
Related: Understanding the Understanding the role of Sars-Cov-2 virulence factor-orf3a in modulating host cell responses- A way to identify host directed therapy Research Project › Medical Sciences MitoInfect: An MitoInfect: An integrative Approach to Dissect Mitochondria associated Host-Pathogen Interactions Research Project › Life Sciences & Biotechnology Unraveling Host-Pathogen Unraveling Host-Pathogen Dynamics and Anti-infective Therapeutics Using CRISPR-Cas9 for tackling Multidrug-Resistant Pseudomonas aeruginosa infection Research Project › Life Sciences & Biotechnology Elucidating the Elucidating the Molecular Interplay of Interferon-Gamma, Heme Oxygenase-1, Carbon Monoxide, and Calcium Signaling in the Regulation of Autophagy and Mycobacterium tuberculosis Clearance Research Project › Life Sciences & Biotechnology Functional dissection Functional dissection of SERINC5-associated regulatory network in viral infection Research Project › Life Sciences & Biotechnology
Dentistry on Wheels- Awareness/ onsite treatment program for oral pre-cancer / cancer for rural population near capital region of north Indian state Uttar Pradesh

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Section: Medical Sciences (Research Project)
Value Addition for Nutrient Bioactive Compounds by Layer Deposition Using 3D Bio-printing

NA

Section: Agricultural Sciences (Research Project)
Related: Value addition Value addition for nutrient bioactive compounds by layer deposition using 3D bio printing Research Project › Engineering Sciences Development of Development of low-cost 3D printing technology for personalized nutritious food preparation Research Project › Engineering Sciences 3D Bioprinting 3D Bioprinting Biomimetic Dermo-Epidermal Construct using Engineered Silk Spidroin with Vasculature Guidance for Skin Tissue Regeneration and Organotypic Tissue Model Research Project › Life Sciences & Biotechnology Investigations on Investigations on the Magnetorheological Finishing of Polymer-based 3D Printed Free-form Surfaces to Enhance their Functional Performance Research Project › Engineering Sciences selective laser selective laser melted low modulus beta Titanium alloy (Ti-Nb) bone implant with surface bio functionalization Research Project › Engineering Sciences
Developing bioplastic blends for food packaging using polyhydroxyalkanoate and violacein from Himalayan bacterium Iodobactersp

NA

Section: Life Sciences & Biotechnology (Research Project)
Related: Developing bioplastic Developing bioplastic blends for food packaging using polyhydroxyalkanoate & violacein from Himalayan bacterium Iodobactersp Research Project › Engineering Sciences
Breast and Ovarian Cancer Awareness

NA

Section: Medical Sciences (Research Project)
Related: Identification of Identification of xenostrogen induced spontaneous mutations & changes in promoter methylation status in the cancer causing genes BRCA1, BRCA2 & P53 in breast, Ovarian, Prostate & Pancreatic cancers Research Project › Medical Sciences Using magnetic Using magnetic nanoswimmers to target and destroy the ovarian cancer metastatic niche Research Project › Medical Sciences Mechanism of Mechanism of Ets-1 transcription factor-mediated metabolic reprogramming and Tumorigenesis in Ovarian cancer Research Project › Medical Sciences Development of Development of Engineered, biocompatible and fluorescent carbon dots for effective targeting and treatment of ovarian cancer Research Project › Engineering Sciences Effect of Effect of Hyperthermia on PARP Inhibition and NOTCH Signaling in Homologous Recombination Stratified Epithelial Ovarian Cancer Research Project › Life Sciences & Biotechnology
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