Discovered indigenously. Safe and stable. Immense therapeutic potential; These derivatives can chelate free iron, prevent oxidative stress by scavenging ROS and simultaneously offer anti-apoptotic effect in vitro. These derivatives have the ability to prevent the formation of iron-mediated. OH as well as scavenge ROS in vivo. We have shown that these derivatives can prevent gastric mucosal oxidative stress and gastropathy by preventing ROS-mediated activation of apoptosis in gastric mucosal cells induced by NSAIDs. This invention provides a new small molecule having gastroprotective efficacy and a new strategy for drug discovery in gastropathy
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