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Novel Cationic 17-Estradiol-Substituted-Estradiol Derivatives with Anti-cancer Activity

Implementing Organization

Indian Institute of Chemical Technology (IICT)

Project Overview

Tested preclinically in triple negative breast tumor animal model (the most aggressive breast cancer model). The molecule is co-formulated in liposomes and developed further in association with Mayo Clinic, USA for treating multiple other aggressive cancers such as melanoma, pancreatic cancer.

Benefits

These Estrogen-structure based molecules have the ability to kill cancer cells of all stages of breast cancer. Other existing estrogen-based or estrogenic anticancer molecule acts against estrogen receptor (ER)-expressing breast cancer cells only. So, this molecule is 'fit-for-all' breast cancerphenotypes, These molecules have anticancer effect against other ER-expressing cancer cells, such as ovarian carcinoma, melanoma, pancreatic cancer, It is orally administrable (whereas estrogenic, anti-breast cancer drug FaslodexTM is intramuscularly injectable only). Hence, it holds the promise to become the first oral breast cancerdrug developed from India

Source

Quick Information
Thrust Areas
Medical Sciences
Focus Area
Cancer Treatment
Output
TRL: Technology Readiness Level
Lab Validation
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