A Promising Therapeutic Lead from Medicinal Plant: Hope for Targeting Cancer and Cancer Stem like Cells
Implementing Organization
Indian Institute of Chemical Engineers
Indian Institute of Chemical Biology (IICB)
About
Abundantly available across India in all seasons Lead molecule: Carbazole Alkaloid (CM-5) medicinal value reported in Charaka Samhita. Non toxic to CD34+ progenitor cell, normal blood cells and astrocytes, normal lung/kidney cell lines from human to monkey. Showed NO acute and chronic toxicity towards normal mice
. Shows anti-proliferative activity against cancer cells(in vitro/ex vivo/ in vivo)
Outcome / Output
In vitor studies with CM-5,Mechanism of Apotosis induced by CM-5, Toxicity of CM-5, In vivo and ex voivo studies with CM-5, Herbal extract enriched with CM-5
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