Medical Sciences

This technology brings forward a cell-based robust assay system to screen small molecules as modifier of aggregation potential of alpha-synuclein, the aggregating protein in Parkinson's disease. This is a screening platform that mimics the fundamental events of protein aggregation and disease in cultured cells.It provides a Cell-based assay system for α-synuclein amyloids whereinUnique combination of two synuclein mutations is used and which avoids animal use completely. This is aRobust fluorescence spectroscopy/ microscopy based assay for amyloid formation.