DNA Vaccine as Immune-prophylaxis Against Kala-azar
Implementing Organization
Indian Institute of Chemical Engineers
Indian Institute of Chemical Biology (IICB)
About
The technology uses a highly conserved membrane protein present in all species of Leishmania as a vaccine antigen for genetic immunization against visceral leishmananiasis or Kala-azar.
Patents
US8524677
Outcome / Output
An indigenous technology having immense prophylactic potential; WHO has identified leishmaniasis as a major and increasing public health problem. Available chemotherapeutic strategies emerging resistant strains and lack of an effective vaccine against Kala-azar intensifies the crisis; The vaccine prevents mortality of the mammal from lethal virulent Leishmania infection and confers sterile protection in tissues that would be infected by Leishmaniaupon exposure.
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