A series of potent inhibitors of toll-like receptor (TLR) 9 as well as dual antagonists of TLR9 and TLR with potential application in auto-immune disease and metabolic syndrome.
Patents
US10662177
Outcome / Output
Potent (nanomolar IC 50) small molecule inhibitora of TLR9 and TLR7: 'ABODINIBS' and 'ADADINIBS'
, Demonstarated oral bioavailabity effiacy in human immune cells and pharmacokinetics in preclinal rodent model, Demonstrated efficacy in apreclinical model of psoriasis
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