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Process for Synthesis of Novel Cationic Amphiphiles Containing N-Hydroxyalkyl Group for Intracellular Delivery of Biologically Active Molecules

Project Overview

Bench scale

Benefits

The procedures for making these novel cationic amphiphiles being simple, the prices of this new transfection reagent should be remarkably lowerthan that of LIPOFECTAMINETM and LIPOFECTIN
TM, The transfection efficiency of the novel cationic amphiphiles are much better than that of LIPOFECTINTM and comparable to or better than the transfection efficiencies ofLIPOFECTAMINETM
, The cationic amphiphiles disclosed in the present invention have been tested positive for transfecting COS 1, Hela, Vero, CV 1 and NIH3T3 cells and the primary cell line, Rat Skin Fibroblasts.

Source

Quick Information
Thrust Areas
Chemical Sciences
Focus Area
Synthesis of Novel Cationic Amphiphiles
Source Title
Output
TRL: Technology Readiness Level
Lab Validation
Patent
US6346516, US6503945, US6541649, IN189751, US6333433
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