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Process for Synthesis of Novel Cationic Amphiphiles Containing N-Hydroxyalkyl Group for Intracellular Delivery of Biologically Active Molecules

Implementing Organization

Indian Institute of Chemical Engineers
Indian Institute of Chemical Technology (IICT)

About

Bench scale

Patents

US6346516, US6503945, US6541649, IN189751, US6333433

Outcome / Output

The procedures for making these novel cationic amphiphiles being simple, the prices of this new transfection reagent should be remarkably lowerthan that of LIPOFECTAMINETM and LIPOFECTIN TM, The transfection efficiency of the novel cationic amphiphiles are much better than that of LIPOFECTINTM and comparable to or better than the transfection efficiencies ofLIPOFECTAMINETM , The cationic amphiphiles disclosed in the present invention have been tested positive for transfecting COS 1, Hela, Vero, CV 1 and NIH3T3 cells and the primary cell line, Rat Skin Fibroblasts.
Quick Information
Thrust Areas
Chemical Sciences
Focus Area
Synthesis of Novel Cationic Amphiphiles
Status
completed
Contact
director@iict.res.in
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