Research Projects

The present proposal is aimed at exploring the reactivity patterns of vinyl radicals emanating from photoredox addition of thiols on terminal alkynes. The project is primarily based on the research work of Mentor’s (Dr. Bhahwal) group, wherein they have found that vinyl radical emanating from photoredox reaction of alkynes with thiyl radical can be utilized for synthetically challenging reactions ranging from geminal difunctionalizations, vicinal functionalization to cyclization to provide direct one-pot access to some of the medicinally important molecules. Notably, vinyl radicals are usually designated as sigma and pi type radicals and can have a bent or a linear structure, wherein, its structure is a key factor in controlling the outcome of these reactions providing transformations that are otherwise difficult to access via conventional methodologies. Besides, the weak C-S bond in these systems has the effect of desymmetrizing the molecule and allows more selective nucleophilic substitution reactions that can’t be accomplished in the C-C isosteric molecules, with exquisite site selectivity. Moreover, it would be of great intrigue to explore different mechanistic pathways of reactions via DFT calculations as the applicant has basic expertise in DFT analysis. Also, we envisage using molecular modeling for the identification of potential bioactive hits, which are part of our continuing drug discovery program.